has reported the very first polymer micelle that can be reversibly dissociated
and formed using light (Macromolecules 2004). Since then, we have
published a series of papers (see
the list below) and established the general design principles based on
light-changeable amphiphilicity and reversible photocrosslinking for
light-controllable polymer micelles. This achievement is of fundamental
importance since it contributes to the basis for the development of
photocontrollable polymer nanocarriers in view of controlled delivery
applications. We pursue this project.
Publications on this topic:
G. Wang, X. Tong, Y. Zhao “Preparation of Azobenzene-Containing
Amphiphilic Diblock Copolymers for Light-Responsive Micellar Aggregates” Macromolecules,
2004, 37, 8911-8917.
J. Jiang, X. Tong, Y. Zhao “A New Design for Light-Breakable Polymer
Micelles” J. Am. Chem. Soc. 2005, 127, 8290-8291.
Tong, G. Wang, A. Soldera, Y. Zhao, “How Can Azobenzene Block Copolymer
Vesicles Dissociated and Reformed by
Light?”, J. Phys, Chem. B 2005,
J. Jiang, X. Tong, D. Morris, Y. Zhao, “Toward Photocontrolled Release
Using Light-Dissociable Block Copolymer Micelles”, Macromolecules 2006,
Jiang, B. Qi, M. Lepage, Y. Zhao, “Polymer Micelles Stabilization-on-Demand
through Reversible Photocrosslinking”,
Macromolecules 2007,40, 790-792. (one of the “Most-Accessed Articles” for Macromolecules in 2007).
Zhao, “Rational Design of Light-Controllable Polymer Micelles”, Chemical
7, 286-294 (invited Highlight article)
J. Babin, M. Lepage, Y. Zhao, “"Decoration" of Shell-Crosslinked Reverse Polymer Micelles
Using ATRP: A New Route to Stimuli-Responsive Nanoparticles", Macromolecules,
2008, 41, 1246-1253